| Certification: | ISO, FDA, HACCP |
|---|---|
| Assay Method: | HPLC |
| Application Form: | Paste, Tablet, Capsule |
| Application: | Food, Health Care Products |
| State: | Powder |
| Extract Source: | Citrus Aurantium L |
| Samples: |
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| Customization: |
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Product Name: Diosmin
Part of used: Fruit
Botanic Name: Citrus Aurantium L
Appearance: Greyish-yellow or pale brown fine powder
Specification: Diosmin 9:1, Diosmin 90.0%
| PRODUCT SPECIFICATIONS | ||
| Product Name: | Diosmin | |
| Botanic Name: | Citrus aurantium L. | |
| Scientific name(Family/Genus/Species) | Rutaceae/Citrus/C.x aurantium | |
| Part of plant | Fruit | |
| Solvent extraction | 50% water & 50% ethanol | |
| Country of Origin: | China | |
| Excipent | None | |
| ANALYSIS ITEMS | SPECIFICATION | TEST METHOD |
| Appearance | Powder | Organoleptic |
| Color | Greyish-yellow or pale brown | Visual |
| Odour & Taste | Characteristic | Organoleptic |
| Identification A. Infrared absorption spectrophotometry(2.2.24) B.Examine the chromatorgrams obtained in the Assay |
Comparaison diosmin CRS The principal peak in the chromatorgram obtained with the test solution issimilar in retention time and size to the principal peak in the chromatogram obtained withreference solution(a) |
HPTLC |
| Solubility | Practically insoluble in water, soluble in dimethyl sulphoxide, practically insoluble in alcohol, It dissolves in dilute solutions of alkali hydroxides | |
| Diosmin | NLT 90.0% | HPLC |
| Hydrocarbons PAHs | ≤ 50 ppb -Reg.UE 1933/2015 | GC-MS |
| Benzo(a)pyren | ≤ 10 ppb -Reg.UE 1933/2015 | GC-MS |
| Iodine | ≤0.1% | |
| Impurity A: acetoisovanillone | ≤1.0% | HPLC |
| Impurity C: isorhoifin | ≤3.0% | HPLC |
| Impurity E: linarin | ≤3.0% | HPLC |
| Impurity F: diosmitin | ≤3.0% | HPLC |
| Radioactivity | ≤ 600 Bq/Kg -Reg. CE 1409/2009 | |
| Apparent density | 0.2-0.6g/ml | |
| Sieve Analysis | 100% pass through 5 micron | USP39 <786> |
| Loss on drying | ≤ 6.0% | Eur.Ph.9.0 [2.5.12] |
| Total Ash | ≤ 0.2% | Eur.Ph.9.0 [2.4.16] |
| Lead (Pb) | ≤ 3.0 mg/kg | Eur.Ph.9.0<2.2.58>ICP-MS |
| Arsenic (As) | ≤ 1.0 mg/kg | Eur.Ph.9.0<2.2.58>ICP-MS |
| Cadmium(Cd) | ≤ 1.0 mg/kg | Eur.Ph.9.0<2.2.58>ICP-MS |
| Mercury(Hg) | ≤ 0.1 mg/kg -Reg.EC629/2008 | Eur.Ph.9.0<2.2.58>ICP-MS |
| Heavy metal | ≤ 10.0 mg/kg | Eur.Ph.9.0 <2.4.8> |
| Solvents Residue | Conform Eur.ph. 9.0 <5,4 > and EC European Directive 2009/32 | Eur.Ph.9.0<2.4.24> |
| Pyidine | ≤ 200ppm | HPGC |
| Methanol | ≤ 3000ppm | HPGC |
| Ethanol | ≤ 5000ppm | HPGC |
| Pesticides Residues | Conform Regulations(EC) No.396/2005 including annexes and successive updates Reg.2008/839/CE | Gas Chromatography |
| Aerobic bacteria(TAMC) | ≤1000 cfu/g | USP39 <61> |
| Yeast/Moulds(TAMC) | ≤100 cfu/g | USP39 <61> |
| Bile-tol.gram- b./Enterobact.: | ≤100 cfu/g | |
| Escherichia coli: | Absent in 1g | USP39 <62> |
| Salmonella: | Absent in 25g | USP39 <62> |
| Staphylococcus aureus: | Absent in 1g | |
| Aflatoxins B1 | ≤ 5 ppb -Reg.EC 1881/2006 | USP39 <62> |
| Aflatoxins ∑ B1, B2, G1, G2 | ≤ 10 ppb -Reg.EC 1881/2006 | USP39 <62> |
Diosmin is a yellow to claybank powder.Diosmin is a flavanone glycoside found abundantly in citrus fruits.
Diosmin is also a potential sedative, possibly acting through opioid or adenosine receptors.Diosmin exhibited pronounced anticancer activity against some selected human carcinoma cell lines.Some in vitro results applied only to the aglycone form.
1.Diosmin has antioxidant, antiinflammatory, hypolipidemic, vasoprotective and anticarcinogenic and cholesterol
lowering actions
2.Diosmin can inhibit following enzymes: Phospholipase A2, lipoxygenase, HMG-CoA reductase and
cyclo-oxygenase.
3.Diosmin can improve the health of capillaries by reducing the capillary permeabilit
4.Diosmin can be used to reduce hay fever and other allergic conditions by inhibiting the release of
histamine from mast cells.
5.Diosmin can excite the heart and shrink the blood vessel, and then causes the hypertension.
1. Applied in food field, Diosmin is used as a flavor enhancer and sweetener in a wide variety of alcoholicbeverage,
dessert foods and savory foods;
2. Applied in cosmetics, Diosmin can added into toothpaste and mouth wash ;
3. Applied in pharmaceutical field, Diosmin is mainly used to reducing the bitterness of in form.
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