| Customization: | Available |
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| Certification: | ISO, FDA, HACCP |
| Assay Method: | HPLC |
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Product Name: Diosmin
Part of used: Fruit
Botanic Name: Citrus Aurantium L
Appearance: Greyish-yellow or pale brown fine powder
Specification: Diosmin 9:1, Diosmin 90.0%
| PRODUCT SPECIFICATIONS | ||
| Product Name: | Diosmin | |
| Botanic Name: | Citrus aurantium L. | |
| Scientific name(Family/Genus/Species) | Rutaceae/Citrus/C.x aurantium | |
| Part of plant | Fruit | |
| Solvent extraction | 50% water & 50% ethanol | |
| Country of Origin: | China | |
| Excipent | None | |
| ANALYSIS ITEMS | SPECIFICATION | TEST METHOD |
| Appearance | Powder | Organoleptic |
| Color | Greyish-yellow or pale brown | Visual |
| Odour & Taste | Characteristic | Organoleptic |
| Identification A. Infrared absorption spectrophotometry(2.2.24) B.Examine the chromatorgrams obtained in the Assay |
Comparaison diosmin CRS The principal peak in the chromatorgram obtained with the test solution issimilar in retention time and size to the principal peak in the chromatogram obtained withreference solution(a) |
HPTLC |
| Solubility | Practically insoluble in water, soluble in dimethyl sulphoxide, practically insoluble in alcohol, It dissolves in dilute solutions of alkali hydroxides | |
| Diosmin | NLT 90.0% | HPLC |
| Hydrocarbons PAHs | ≤ 50 ppb -Reg.UE 1933/2015 | GC-MS |
| Benzo(a)pyren | ≤ 10 ppb -Reg.UE 1933/2015 | GC-MS |
| Iodine | ≤0.1% | |
| Impurity A: acetoisovanillone | ≤1.0% | HPLC |
| Impurity C: isorhoifin | ≤3.0% | HPLC |
| Impurity E: linarin | ≤3.0% | HPLC |
| Impurity F: diosmitin | ≤3.0% | HPLC |
| Radioactivity | ≤ 600 Bq/Kg -Reg. CE 1409/2009 | |
| Apparent density | 0.2-0.6g/ml | |
| Sieve Analysis | 100% pass through 5 micron | USP39 <786> |
| Loss on drying | ≤ 6.0% | Eur.Ph.9.0 [2.5.12] |
| Total Ash | ≤ 0.2% | Eur.Ph.9.0 [2.4.16] |
| Lead (Pb) | ≤ 3.0 mg/kg | Eur.Ph.9.0<2.2.58>ICP-MS |
| Arsenic (As) | ≤ 1.0 mg/kg | Eur.Ph.9.0<2.2.58>ICP-MS |
| Cadmium(Cd) | ≤ 1.0 mg/kg | Eur.Ph.9.0<2.2.58>ICP-MS |
| Mercury(Hg) | ≤ 0.1 mg/kg -Reg.EC629/2008 | Eur.Ph.9.0<2.2.58>ICP-MS |
| Heavy metal | ≤ 10.0 mg/kg | Eur.Ph.9.0 <2.4.8> |
| Solvents Residue | Conform Eur.ph. 9.0 <5,4 > and EC European Directive 2009/32 | Eur.Ph.9.0<2.4.24> |
| Pyidine | ≤ 200ppm | HPGC |
| Methanol | ≤ 3000ppm | HPGC |
| Ethanol | ≤ 5000ppm | HPGC |
| Pesticides Residues | Conform Regulations(EC) No.396/2005 including annexes and successive updates Reg.2008/839/CE | Gas Chromatography |
| Aerobic bacteria(TAMC) | ≤1000 cfu/g | USP39 <61> |
| Yeast/Moulds(TAMC) | ≤100 cfu/g | USP39 <61> |
| Bile-tol.gram- b./Enterobact.: | ≤100 cfu/g | |
| Escherichia coli: | Absent in 1g | USP39 <62> |
| Salmonella: | Absent in 25g | USP39 <62> |
| Staphylococcus aureus: | Absent in 1g | |
| Aflatoxins B1 | ≤ 5 ppb -Reg.EC 1881/2006 | USP39 <62> |
| Aflatoxins ∑ B1, B2, G1, G2 | ≤ 10 ppb -Reg.EC 1881/2006 | USP39 <62> |
Diosmin is a yellow to claybank powder.Diosmin is a flavanone glycoside found abundantly in citrus fruits.
Diosmin is also a potential sedative, possibly acting through opioid or adenosine receptors.Diosmin exhibited pronounced anticancer activity against some selected human carcinoma cell lines.Some in vitro results applied only to the aglycone form.
1.Diosmin has antioxidant, antiinflammatory, hypolipidemic, vasoprotective and anticarcinogenic and cholesterol
lowering actions
2.Diosmin can inhibit following enzymes: Phospholipase A2, lipoxygenase, HMG-CoA reductase and
cyclo-oxygenase.
3.Diosmin can improve the health of capillaries by reducing the capillary permeabilit
4.Diosmin can be used to reduce hay fever and other allergic conditions by inhibiting the release of
histamine from mast cells.
5.Diosmin can excite the heart and shrink the blood vessel, and then causes the hypertension.
1. Applied in food field, Diosmin is used as a flavor enhancer and sweetener in a wide variety of alcoholicbeverage,
dessert foods and savory foods;
2. Applied in cosmetics, Diosmin can added into toothpaste and mouth wash ;
3. Applied in pharmaceutical field, Diosmin is mainly used to reducing the bitterness of in form.
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About Us
KINDHERB is a hightech enterprise specializing in and developing plant extracts. Since now we have already more than 10 years experience. We are committed to the development and development of traditional Chinese herbal medicine, with strict GAP raw material base, GMP production anagement and ISO9001/ISO22000/Kosher/HALAL quality certification, and many wellknown in the food, health products, medicine and cosmetics industries and the world. Enterprises have established long-term strategic cooperative relations.
KINDHERB office is located in Hangzhou, Zhejiang province. We specializes in the production and marketing of Rosehip extract, Saw palmetto extract, Guarana extract, Yerba mate extract, Acerola extract, Bilberry extract, Coleus forskolii extract, Resveratrol, Berberis aristata extract, and other natural ingredients and high purity extracts of plant functional ingredients and standardized extracts.
KINDHERB pays attention to the combination of technology and technology, and the market demand ensures that the product has high technology content and wide applicability, and attaches great importance to environmental protection and high efficiency. At present, the company's products have been widely recognise by domestic and foreign companies.
Shipment & Payment
Our Services and Guarantees:
1 : We have our own quality inspection report for each shipment.
2: 20-50 grams of samples are provided free of charge for customers to check the quality
3. If there are any quality problems, we will unconditionally exchange the prroduct or refund.
FAQ:
1. What's the payment terms?
T/T ,Paypal, Western Union.
2. MOQ?
1kg, some special product can be 10grams.
3. What's your lead time?
Usually we arrange the shipment in 5-7 working days after the payment cleared.
4.What is your sample policy?
Free sample is available while you afford the courier charge.
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