| Certification: | ISO, FDA, HACCP |
|---|---|
| Assay Method: | HPLC |
| Application Form: | Paste, Tablet, Capsule |
| Application: | Food, Health Care Products |
| State: | Powder |
| Extract Source: | Citrus Aurantium |
| Samples: |
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| Customization: |
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Product Name: Hesperidin
Botanic Name: Citrus aurantium L.
Specification: 10%~ 95.0% Hesperidin
Test Method: HPLC
Part of used: Fruit
Appearance: Light-cream Yellow Fine Powder
| PRODUCT SPECIFICATIONS | ||
| Product Name: | Hesperidin powder | |
| Botanic Name: | Citrus aurantium L. | |
| Scientific name(Family/Genus/Species) | Rutaceae/Citrus/C.x aurantium | |
| Part of plant | Fruit | |
| Solvent extraction | 50% water & 50% ethanol | |
| Country of Origin: | China | |
| Excipent | None | |
| ANALYSIS ITEMS | SPECIFICATION | TEST METHOD |
| Appearance | Fine powder | Organoleptic |
| Color | Light-cream Yellow | Visual |
| Odour & Taste | Characteristic | Organoleptic |
| Identification | Identical to R.S. sample | HPTLC |
| Hesperidin | 90.0% 95.0% | HPLC |
| Solubility | Smally soluble in water | |
| Hydrocarbons PAHs | ≤ 50 ppb -Reg.UE 1933/2015 | GC-MS |
| Benzo(a)pyren | ≤ 10 ppb -Reg.UE 1933/2015 | GC-MS |
| Radioactivity | ≤ 600 Bq/Kg -Reg. CE 1409/2009 | |
| Apparent density | 0.3-0.7g/ml | |
| Sieve Analysis | 100% through 80 mesh | USP39 <786> |
| Loss on drying | ≤ 5.0% | Eur.Ph.9.0 [2.5.12] |
| Total Ash | ≤ 5.0% | Eur.Ph.9.0 [2.4.16] |
| Lead (Pb) | ≤ 3.0 mg/kg | Eur.Ph.9.0<2.2.58>ICP-MS |
| Arsenic (As) | ≤ 1.0 mg/kg | Eur.Ph.9.0<2.2.58>ICP-MS |
| Cadmium(Cd) | ≤ 1.0 mg/kg | Eur.Ph.9.0<2.2.58>ICP-MS |
| Mercury(Hg) | ≤ 0.1 mg/kg -Reg.EC629/2008 | Eur.Ph.9.0<2.2.58>ICP-MS |
| Heavy metal | ≤ 10.0 mg/kg | Eur.Ph.9.0 <2.4.8> |
| Solvents Residue | Conform Eur.ph. 9.0 <5,4 > and EC European Directive 2009/32 | Eur.Ph.9.0<2.4.24> |
| Pesticides Residues | Conform Regulations(EC) No.396/2005 including annexes and successive updates Reg.2008/839/CE | Gas Chromatography |
| Aerobic bacteria(TAMC) | ≤1000 cfu/g | USP39 <61> |
| Yeast/Moulds(TAMC) | ≤100 cfu/g | USP39 <61> |
| Bile-tol.gram- b./Enterobact.: | ≤100 cfu/g | |
| Escherichia coli: | Absent in 1g | USP39 <62> |
| Salmonella: | Absent in 25g | USP39 <62> |
| Staphylococcus aureus: | Absent in 1g | |
| Aflatoxins B1 | ≤ 5 ppb -Reg.EC 1881/2006 | USP39 <62> |
| Aflatoxins ∑ B1, B2, G1, G2 | ≤ 10 ppb -Reg.EC 1881/2006 | USP39 <62> |
1)Hesperidin is a flavanone glycoside found abundantly in citrus fruits. Its aglycone form is called hesperetin. Its name is derived from the word "hesperidium", the kind of fruit produced by citrus trees.
2)Hesperidin is believed to play a role in plant defense. It acts as an antioxidant according to in vitro studies.Various preliminary studies reveal novel pharmaceutical properties, none of which has been confirmed as applicable to humans.
3)Hesperidin reduced cholesterol and blood pressure in rats. In a mouse study, large doses of hesperidin decreased bone density loss.Another animal study showed protective effects against sepsis. In vitro and in laboratory research, hesperidin has antinflammatory effects.
4)Hesperidin is also a potential sedative, possibly acting through opioid or adenosine receptors.Hesperidin exhibited pronounced anticancer activity against some selected human carcinoma cell lines.Some in vitro results applied only to the aglycone form.
5)Hesperidin also showed potential to penetrate the blood-brain barrier in an in vitro model.
1.Hesperidin are applied in cholesterol-lowering effect, help treating diabetes
2.Hesperidin are applied in naringin (and grapefruit)
can interfere with certain drugs including calcium channel blockers,sedatives, cholesterol lowering drugs, and estrogen.
3. Hesperidin are applied in naringin and could therefore increase its fat burning acti
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